Antitumor and immunomodulating activities of a beta-glucan obtained from liquid-cultured Grifola frondosa
Suzuki I, Hashimoto K, Oikawa S, Sato K, Osawa M, Yadomae T
The effects of the beta-1,3-glucan,
LELFD, obtained from liquid-cultured mycelium of Grifola
frondosa, on the growth of syngeneic tumors
and immune responses in mice were examined. In
Meth A or IMC solid tumor systems, LELFD
administered intraperitoneally (i.p.) or
intralesionally (i.l.) exhibited significant
antitumor effects. However, the growth of L1210 and
P388 leukemias was unaffected by the injection
of LELFD. The injection of LELFD i.p.
enhanced the activities of natural killer
cells and macrophages in mice. LELFD also enhanced the
antibody response when it was injected
i.p. with sheep red blood cells into mice. Furthermore, it
was found that LELFD could activate the
alternative complement pathway.
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