Effects of Lentinus edodes, Grifola frondosa and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N-butanolnitrosoamine.
Kurashige S, Akuzawa Y, Endo F
Department of Laboratory Sciences, Gunma University School of Health Sciences, Japan.
ICR mice were treated with a carcinogen, N-butyl-N'-butanolnitrosoamine BBN), every day for 8 consecutive weeks and the effects of oral administration of edible mushrooms on the induction of urinary bladder carcinoma and on the activities of macrophages and lymphocytes were studied. Bladder carcinoma were found in all 10 mice (100%) treated with BBN alone, while we observed carcinoma only in 9 of 17 mice (52.9%), in 7 of 15 mice (46.7%) and 13 of 20 mice (65.0%) treated with Lentinus edodes, Grifola frondosa and Pleurotus ostreatus, respectively. Chemotactic activity of macrophages was suppressed in mice treated with BBN alone but maintained almost the normal level in mice treated with BBN plus Lentinus, Grifola or Pleurotus.
Lymphocytes collected from mice treated
with BBN plus each mushroom showed almost normal
blastogenic response against concanavalin
A, although those from mice treated with BBN alone
completely retarded their response. Cytotoxic
activity of lymphocytes against Yac-1 cells was
also maintained at a normal level in mice
treated with BBN plus each mushroom. Whereas in
mice treated with BBN alone significant
depression of NK cell activity occurred. Significantly higher cytotoxic activity against P-815
cells was observed in lymphocytes from mice treated with
BBN plus each mushroom than that in lymphocytes
from normal mice or mice treated with BBN
alone.
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