Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake).
Kubo K, Aoki H, Nanba H
Yukiguni Maitake Co., Ltd. Niigata, Japan.
The fruit body of Grifola frondosa (maitake),
Basidiomycetes was confirmed to contain
substances with anti-diabetic activity.
When 1 g/d of powdered fruit body of maitake was given
orally to a genetically diabetic mouse
(KK-Ay), blood glucose reduction was observed, in
contrast to the control group in which
the blood glucose increased with ageing. Moreover, levels
of insulin and triglyceride in plasma demonstrated
a change similar to blood glucose with feeding
of maitake. Ether-ethanol-soluble (ES)
and hot water-soluble (WS) fractions were prepared
from the fruit body and their hypoglycemic
activity was examined. Blood glucose-lowering
activity was found when ES-fraction or
WS-50% ethanol float (X) fraction was administered
orally, but other WS-fractions were inactive.
These results suggest that the anti-diabetic activity
was present not only in the ES-fraction
consisting of lipid but also in the X-fraction of
peptidoglycan (sugar:protein = 65:35).
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