Aloha Medicinals | Scientific and Technical References

Agaricus Blazei Research

Anti-tumor polysaccharide from the mycelium of liquid-cultured Agaricus blazei mill

Mizuno M, Minato K, Ito H, Kawade M, Terai H, Tsuchida H
Graduate School of Science and Technology, Kobe University, Japan.
Anti-tumor active polysaccharide against Sarcoma 180 was isolated by DEAE-Sepharose CL-6B and Sepharose 4B column chromatography from the hot-water soluble fraction of the mycelium of liquid-cultured Agaricus blazei mill. This polysaccharide did not react with antibodies of anti-tumor polysaccharides such as lentinan, gliforan, and FIII-2-b which is one of anti-tumor polysaccharides from Agaricus blazei. Moreover, the analyses of 13C-NMR and GC-MS suggested that this polysaccharide was preliminarily glucomannan with a main chain of beta-1,2-linked D-mannopyranosyl residues and beta-D-glucopyranosyl-3-O-beta-D-glucopyranosyl residues as a side chain. This polysaccharide was completely different from the anti-tumor polysaccharide from fruiting body of Agaricus blazei, beta-1,6-glucan.

PMID: 10319424, UI: 99252982

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